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Marketed drugs frequently perform worse in clinical practice than in the clinical trials on which their approval is based. Many therapeutic compounds are ineffective for a large subpopulation of patients to whom they are prescribed; worse, a significant fraction of patients experience adverse effects more severe than anticipated. The unacceptable risk—benefit profile for many drugs mandates a paradigm shift towards personalized medicine. However, prior to adoption of patient-specific approaches, it is useful to understand the molecular details underlying variable drug response among diverse patient populations.
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Bioinformatics and variability in drug response: a protein structural perspective

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Bioinformatics and variability in drug response: a protein structural perspective

Metrics details. The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine. J Headache Pain. According to the new ICHD 3 diagnostic criteria a de novo headache occurring with another disorder recognized to be capable of causing it is always diagnosed as secondary.
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