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Rectal medicines (suppositories and enemas)

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Rectal medicines (suppositories and enemas) | Medicines for Children

Rectal administration uses the rectum as a route of administration for medication and other fluids, which are absorbed by the rectum's blood vessels , [Note 1] and flow into the body's circulatory system , which distributes the drug to the body's organs and bodily systems. A drug that is administered rectally will in general depending on the drug have a faster onset, higher bioavailability , shorter peak, and shorter duration than oral administration. In addition, the rectal route bypasses around two thirds of the first-pass metabolism as the rectum's venous drainage is two thirds systemic middle and inferior rectal vein and one third hepatic portal system superior rectal vein. This means the drug will reach the circulatory system with significantly less alteration and in greater concentrations. Unlike intravenous lines, which usually need to be placed in an inpatient environment and require special formulation of sterile medications, [3] a specialized rectal catheter can be placed by a clinician, such as a hospice nurse or home health nurse, in the home. Many oral forms of medications can be crushed and suspended in water to be given via a rectal catheter.
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Rectal administration

This leaflet gives tips about how to give rectal medicines suppositories and enemas to children. This leaflet has been written specifically about the use of medicines in children. Please read this leaflet carefully. Keep it somewhere safe so that you can read it again. Rectal medicines are administered given through the anus into the rectum back passage, or bottom.
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